MS07-P08 Structural characterisation of diruthenium paddlewheel compounds with cytosinato and adeninato ligands Josefina Perles (Departamento de Química Inorgánica, Universidad Autónoma de Madrid, Madrid, Spain) Ángela Valentín-Pérez (Departamento de Química Inorgánica, Universidad Complutense de Madrid, Madrid, Spain) Santiago Herrero (Departamento de Química Inorgánica, Universidad Complutense de Madrid, Madrid, Spain) Reyes Jiménez-Aparicio (Departamento de Química Inorgánica, Universidad Complutense de Madrid, Madrid, Spain)email: josefina.perles@uam.esThe interactions of dimetallic coordination compounds with biological molecules, in particular dirhodium and diruthenium metal-metal bonded complexes with paddlewheel geometry, are currently being invesigated as there is evidence indicating that dirhodium compounds covalently link with DNA, tRNA and proteins. In fact, paddlewheel diruthenium compounds can form metal-protein adducts, acting as inhibitors of C6 rat glioma cell proliferation or as inhibitors of glioma tumour growth in vivo. Open-padlewheel compounds have also been proved helpful for fingerprinting the junctions of RNA structure [1].

Recent works exploring the interactions of diruthenium moieties with biological species have focused on the elucidation of the coordination mode of the ruthenium atoms to the active sites of the potential ligands, as open-paddlewheel species have the tendency to include another bidentate ligand as a fourth bridge yielding a paddlewheel structure and thus gaining stability,

In this work, compounds [Ru2Cl(DPhF)3(cyto)] and [Ru2Cl(DPhF)3(ade)] have been synthesized and characterized by several techniques, including single crystal X-ray diffraction. Supramolecular interactions between these molecules have also been studied, paying particular attention to the intermolecular hydrogen bonds similar to the ones found  in nucleic acids. Interestingly, it was found that compound [Ru2Cl(DPhF)3(cyto)] is the first crystallographycally characterised ruthenium cytosinate, and the coordination mode found in [Ru2Cl(DPhF)3(ade)] had not been previously described for adeninate (or adenine) in the crystal structure of a ruthenium complex.
 
References:

[1] Lozano, G .& Jiménez-Aparicio R. & Herrero S. & Martínez-Salas E. (2016) RNA, 22(3), 1-9.
Keywords: Diruthenium paddlewheel compounds, antitumoral activity, supramolecular interactions