MS01-P05 First steps towards routine serial crystallography at the VMX-i beamline Juan Sanchez-Weatherby (VMXI Beamline, MX Group, Didcot, United Kingdom) James Sandy (VMXi Beamline, MX Group, Diamond Light Source, Didcot, United Kingdom) Agatha Butryn (XFEL Hub, MX Group, Diamond Light Source, Didcot, United Kingdom) Pierre Aller (XFEL Hub, MX Group, Diamond Light Source, Didcot, United Kingdom) Halina Mikolajek (VMXi beamline, MX Group, Diamond Light Source, Didcot, United Kingdom) Mita Charles (GDA Team, Diamond Light Source, Didcot, United Kingdom) Allen Orville (XFEL Hub, MX Group, Diamond Light Source, Didcot, United Kingdom) Thomas Sorensen (VMXi beamline, MX Group, Diamond Light Source, Didcot, United Kingdom)email: juan.sanchez-weatherby@diamond.ac.ukVMXi is the most recent addition to the portfolio of macromolecular crystallography beamlines at Diamond Light Source. VMXi was built in place of the previously existing tuneable I02 beamline and was built as an entirely remote, high throughput in-situ crystallography beamline. The beamline operates in a fully automated fashion and the users input data collection parameters and evaluate results via a remote web interface. The beamline is in the initial phases of user operation but its unique optical properties and very high flux make it particularly well suited for serial crystallography. During the past few months, several proof of principle experiments have been carried out at VMXi in collaboration with members of the XFEL hub. These experiments highlight the scientific opportunities that this beamline will offer and enable us to shape the best model for the VMXi user program that better suits the needs of the user community. The results from these experiments will also provide the test bed for improving the autoprocessing pipelines needed for the high volume of data produced by this beamline and XFEL beamlines around the world.  We will present examples of the different sample delivery systems tested, how the resulting data are collected and processed, and discuss the options of how the beamline could be best used by the growing UK XFEL community.References:

Keywords: in-situ, serial crystallography, multilayer monochromator