MS31-P04 Synthesis, structure and chemical properties of copper(II) complexes with 2,2‘-bipyridine and l-serine: porous materials and polymorphism Darko Vušak (Department of Chemistry, Faculty of Science, University of Zagreb, Zagreb, Croatia) Biserka Prugovečki (Department of Chemistry, Faculty of Science, University of Zagreb, Zagreb, Croatia) Dubravka Matković-Čalogović (Department of Chemistry, Faculty of Science, University of Zagreb, Zagreb, Croatia)email: dvusak@chem.pmf.hrConsidering copper as an essential metal and being the key element for regular function of some proteins, copper(II) complexes with amino acids are often used as model systems for metal-protein interactions.[1] Furthermore, copper(II) complexes with heterocyclic bases and amino acids readily interact with DNA molecules through hydrogen bonds and π-interactions. These comopunds showed prominent antiproliferative activity against a series of tumor cell lines.[2] Since 2,2‘-bipyridine and serine are capable of forming various types of noncovalent interactions, their complexes may form predictible supramolecular motifs, thus being important in crystal engineering. In our latest research we have prepared porous complexes of copper(II) with 1,10-phenantholine and l-serine which we were able to interconvert into each other in the solid state under controlled conditions.[3]
Herein, we present the first four crystal structures of copper(II) complexes with 2,2‘-bipyridine (bpy) and l-serine (ser) obtained by fine tuning of synthetic conditions: [Cu(ser)(H2O)(bpy)]2SO4·6H2O (1), [Cu(ser)(bpy)(CH3OH)]2SO4·3CH2OH (2), and two polymorphs of the [Cu(ser)(H2O)(bpy)]2SO4 (3a and 3b). The two complexes with solvent of crystallization (1 and 2) both have porous structures, while the two polymorphs (3a and 3b) do not, but all of them can be compared to the structures with phenanthroline. On the other hand, chemical properties of bipyridine complexes seem to be somewhat different then those with phenanthroline. Solution based and mechanochemical syntheses are discussed, as well as the chemical properties of these compelxes.
 
References:

[1] Bordignon Luiz, M. T. et. al. (1999). Inorg. Chim. Acta, 287, 134-141.

[2] Santini, C. (2014). Chem. Rev., 114, 815-862.

[3] Vušak, D. et. al. (2017). Cryst. Growth Des., 17, 6049-6061.

Keywords: copper(II) complex, crystal structure, solvatomorphism