MS35-P04 Design of new bi- and tri-periodic indium MOFs and their catalytic activity in the Strecker and Ugi multicomponents reactions Daniel Reinares Fisac (Materials Science Factory, Department of New Architectures in Materials Chemistry - Materials Science Institute of Madrid (ICMM), Spanish National Research Council (CSIC), Madrid, Spain) Lina María Aguirre-Díaz (Materials Science Factory, Department of New Architectures in Materials Chemistry - Materials Science Institute of Madrid (ICMM), Spanish National Research Council (CSIC)., Madrid, Spain) Marta Iglesias (Materials Science Factory, Department of New Architectures in Materials Chemistry - Materials Science Institute of Madrid (ICMM), Spanish National Research Council (CSIC)., Madrid, Spain) Enrique Gutiérrez-Puebla (Materials Science Factory, Department of New Architectures in Materials Chemistry - Materials Science Institute of Madrid (ICMM), Spanish National Research Council (CSIC)., Madrid, Spain) Felipe Gándara (Materials Science Factory, Department of New Architectures in Materials Chemistry - Materials Science Institute of Madrid (ICMM), Spanish National Research Council (CSIC)., Madrid, Spain) M. Ángeles Monge (Materials Science Factory, Department of New Architectures in Materials Chemistry - Materials Science Institute of Madrid (ICMM), Spanish National Research Council (CSIC)., Madrid, Spain)email: daniel.reinares@icmm.csic.esMetal-organic Frameworks (MOFs) are a type of materials made of the combination of organic linkers and metal centres. [1] Our group has extensively carried out research focused on the design and preparation of MOFs with group 13-elements, which have shown great potential in the field of heterogeneous catalysis. [2] In particular, indium-MOFs have shown remarkable activity as Lewis-acid catalysts for multicomponent reactions (MCRs) such as Strecker and Ugi reactions (involving the reaction of  ketones, amines and cyanides in the former, and aldehydes, amines, carboxylic acids and cyanides in the later). With the use of In-MOFs, these MCRs can be carried out in one step and under Green conditions by reducing the amount of solvent, at room temperature, and reaching high yields. We have prepared three different MOFs with the combination of indium and the tritopic linker 1,3,5-Tris(4-carboxyphenyl)benzene (H3btb), denoted InPF-110, InPF-50, and InPF-51. InPF-110 exhibits a mesoporous, three-periodic structure formed by trimetric inorganic secondary building unit with the metal centres in octahedral coordination environment. This MOF, which allows the diffusion of multiple substrate inside the pores, has demonstrated exceptional activity in the Strecker reaction. On the other hand, InPF-50 and InPF-51 exhibit two periodic structures with entangled layers. Presence of metal centers with low coordination number, large number ofaccessible open-metal sites, and presence of Lewis basic centers result in excellent catalytic activity of these MOFs in the Ugi reaction.References:

[1] Furukawa, H., Cordova, K., O’Keeffe, M., Yaghi, O. (2013) Science, 341, 974–986.

[2] Aguirre-Díaz, L. M., Reinares-Fisac, D., Iglesias, M., Gutiérrez-Puebla, E., Gándara, F., Snejko, N., Monge, M.A. (2017). Coordination Chemistry Reviews, 335, 1-27.
Keywords: MOF,catalysis,porous