MS36-P02 Powder X-ray diffraction structural characterization and applications of cis-[CoII(κ2N,N’-1,10-phenanthroline-5,6-dione)2Cl2Olufunso Olumide Abosede(Department of Chemistry, Federal University Otuoke, Otuoke via Yenagoa, Nigeria)José Fernandes(Dipartimento di Scienza e Alta Tecnologia, Università dell’Insubria, via Valleggio 11, 22100, Como, Italy)Simona Galli(Dipartimento di Scienza e Alta Tecnologia, Università dell’Insubria, via Valleggio 11, 22100, Como, Italy)email: abosedeoo@fuotuoke.edu.ng1,10-phenanthroline-5,6-dione (phendione) is a versatile ligand that has been used in the preparation of stable homo- and hetero-metallic complexes with a wide range of transition metal ions [1]. Phendione itself possesses electrochemical and strong biological activity including antifungal, DNA and cytotoxic activity [2-3]. It has been shown that its biological activity increases upon complexation with a wide range of metal ions, such as Ag+, Cu2+, Pt2+ [2-3].
This poster presents the synthesis and powder X-ray diffraction (PXRD) structural characterization of cis-[CoII(κ2N,N’-1,10-phenanthroline-5,6-dione)2Cl2]. PXRD details, unit cell parameters, and space group for cis-[CoII(κ2N,N’-1,10-phenanthroline-5,6-dione)2Cl2], C24H12Cl2CoN4O4, are reported [a = 41.4951 (13) Å, b = 8.2768 (2) Å, c = 12.4994 (3) Å, unit cell volume V = 4292.9 (2) ų, Z = 8, and space group Fdd2].
Spectroscopic characterization and the antibacterial activity of this complex against Bacillus subtilis, Staphylococcus epidermidis, Staphylococcus aureus, and Klebsiella pneumonia will also be presented and discussed. References:
[1] Viganor. L. et al. (2016) J. Antimicrob. Chemother. 71, 128-134.
[2] Roy S. et al. (2008) ChemMedChem 3, 1427–1434.