MS32-P12 X-Ray Study of new titanium (III) complexes derived from salicylic acid derivatives and N,N-bidentate ligands or monodentate O, N,-ligands Peter Herich (Institute of Physical Chemistry and Chemical Physics, Central Laboratories, Faculty of Chemical and Food Technology, Slovak University of Technology in Bratislava, Radlinského 9, SK-81237, Bratislava, Slovakia) Jozef Kožíšek (Institute of Physical Chemistry and Chemical Physics, Faculty of Chemical and Food Technology, Slovak University of Technology in Bratislava, Radlinského 9, SK-81237, Bratislava, Slovakia)email: peter.herich@stuba.sk
The Titanium complexes stand for a new category of potential anticancer compound. The first studies of titanium complexes copied square-planar arrangement of cis-platin complexes. These complexes show a significant anticancer activity for a wide range of cell lines of cancer [1]. We synthesized new titanium complexes derived from salicylic acid derivatives (as 3-methoxysalicylic acid) and N,N-bidentate ligands (as 1,10-phenanthroline) or monodentate O, N,-ligands (as imidazole) [2]. These complexes were prepared in monocrystal form and suitable crystals were selected for X-ray experiment. All experiments were performed by Stoe STADIVARI diffractometer with a Dectris Pilatus 300 K detector and with an Genix3D Cu HF source (Cu-Kα, λ = 1.54186 Å) at 100 K using a nitrogen gas open-flow cooler Cobra Oxford Cryosystems. Data reduction was performed using X-Area (Stoe, 2017) software package [3]. The crystal structures for measured compounds were solved in OLEX2 software using SHELXT-2015 program via Intrinsic Phasing and refined with SHELXL-2014 by least-squares procedure on F2. Since few efforts have been made towards the synthesis and use of titanium complexes as chemotherapeutic agents, this is an important area of our research.
 
Acknowledgement
This work has been supported by the Ministry of Education, Science, Research, and Sport of the Slovak Republic within the Research and Development Operational Programme for the project “University Science Park of STU Bratislava”, ITMS 26240220084, co-funded by the European Regional Development Fund and also by support of the Research and Development Agency under the contract No. APVV-15-0079 and Scientific Grant Agency of the Slovak Republic VEGA (Project No.1/0871/16).
 
References:

[1] Kaushal, R. et al. (2014). Bioinorganic Chemistry and Applications. 2014, 1-12.

[2] Kucková, L., et al. (2015). Molecules. 20, 2115-2137.

[3] STOE & Cie GmbH (2016). X-Area 1.76, software package for collecting single-crystal data on STOE area-detector

diffractometers, for image processing, scaling reflection intensities and for outlier rejection; Darmstadt, Germany.

Keywords: anticancer activity, titanium complex, salicylic acid.