MS12-P06 Bringing together functional annotations related to structureIn order to understand macromolecular structures archived in the Protein Data Bank (PDB), it is essential to take into consideration the biological context of these molecules. Multiple specialised resources each provide one or more aspects of the biological context, but it takes significant effort to collect and compare all the information that may be relevant to a specific structure.
PDBe-KB (Protein Data Bank in Europe - Knowledge Base) is a new community driven resource under development by PDBe, which will provide functional annotations for structural data that can be used by the scientific community to answer biological questions. PDBe-KB is a collaborative effort between PDBe and a diverse group of biological resources and structural bioinformatics research teams. This new resource will consolidate older services, such as SIFTS, which focuses on providing seamless mappings between PDB entries and other databases, and data from multiple data enrichment projects. These include the FunPDBe project, which aims to collect and distribute highly enriched, valuable annotations that create a comprehensive biological context for structural models, effectively bringing structure to biology.References:
Mir, S. et. al. (2018) Nucleic acids research, 46, D486-D492Keywords: Protein Data Bank, Functional annotation, PDBe-KB