MS36-P12 Structural Analysis and Antimicrobial Activity of a New Dithiocarbazate and its Copper(II) Complex Francielle Lima (Chemistry Institute - University of Brasilia, Brasilia, Brazil) Thayná Silva (Biology Institute - University of Franca, Franca, Brazil) Carlos Martins (Biology Institute - University of Franca, Franca, Brazil) Claudia Gatto (Chemistry Institute - University of Brasilia, Franca, Brazil)email: franci_l@hotmail.com.brDithiocarbazates and their metal complexes have been the subject of many studies because they have a wide range of pharmaceutical applications and also because of their chemical and structural versatility.[1,2] These Schiff bases present themselves in their varied structures coordination sites and allow the formation of complexes with several transition metals. Based on our interest in this class of compounds, the present study describe the synthesis and crystallography evaluation of the new ligand 2-hydroxyacetophenone-S-dithiocarbazate (H2L1) and its copper(II) complex, [(CuL1)2]. The compounds were characterized by elemental analysis and spectral measurements (IR, UV-Vis, 1H NMR and 13C NMR). The packing architectures revealed by single crystal X-ray diffraction analysis showed bifurcated intramolecular hydrogen bonds which are responsible for the formation of a dimer-like structure. The ligand adopts an E configuration and tautomeric and thione form. The copper(II) complex is a dimeric structure with a distorted square planar coordination geometry around each copper atom. The metal centers are connected by µ2-oxo bridges with ONS-donor ligands. The distance between the metal atoms of is 2.926(6) Å, long enough to have any metal-metal interaction. In addition, the biological properties of the compounds were evaluated against a variety of bacteria and fungi. In all experiments, due the structure and properties of the copper(II) complex was a greater antimicrobial activity observed compared to the free dithiocarbazate.References:

[1] Zangrando, E. et al. (2015). Inorg. Chim. Acta. 427, 278-284.

[2] Mirza, A. H. et al. (2014). Polyhedron. 81, 723-727.

Keywords: Crystallography, Dithiocarbazates, Biological Analysis