MS36-P35 Crystal structures and bioactivity studies of four novel chalcone and flavonol copper(II) complexes containing Schiff base co-ligand Aleksandar Višnjevac (Zavod za fizičku kemiju, Institut Ruđer Bošković, Zagreb, Croatia) Adnan Zahirović (Department of Chemistry, Faculty of Science, University of Sarajevo, Sarajevo, Bosnia & Herzegovina) Irnesa Osmanković (Department of Chemistry, Faculty of Science, University of Sarajevo, Sarajevo, Bosnia & Herzegovina) Emir Turkušić (Department of Chemistry, Faculty of Science, University of Sarajevo, Sarajevo, Bosnia & Herzegovina) Emira Kahrović (Department of Chemistry, Faculty of Science, University of Sarajevo, Sarajevo, Bosnia & Herzegovina)email: aleksandar.visnjevac@irb.hrFour new heteroleptic copper(II) complexes having chalcone or flavonol ligands and Schiff base (N-phenyl-5-chlorosalicylideneimine) as co-ligand were prepared, chemically and structurally characterized and investigated as functional biomimetic catecholase models. The complexes were prepared by the solution synthesis and crystal and molecular structures were determined by X-ray diffraction. Complexes were chemically characterized by elemental analysis, infrared and electron spectroscopy as well as by electrochemical measurements. Copper(II) chalcone complexes, with square-pyramidal CuO4N core, are binuclear, featuring phenolate oxygen from the Schiff base as a bridging ligand, while copper (II) flavonol complexes are mononuclear, and reveal a square planar CuO3N coordination core. Catalytic activity of the complexes in 3,5-di-tert-butylcatechol oxidation was confirmed by spectrophotometric and electrochemical measurements. Kinetic measurements revealed that the binuclear (chalcone-containing) complexes have enhanced catalytic activity as compared to the mononuclear Cu(II) flavonol complexes. Relatively high kcat values (300 – 750 h-1) confirmed their respectable biomimetic catecholase-like activity.
 
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Keywords: copper, Schiff base, chalcone, flavonol, catecholase activity